Post-discharge impact and cost-consequence analysis of prehabilitation in high-risk patients undergoing major abdominal surgery: secondary results from a randomised controlled trial.

BACKGROUND: Prehabilitation may reduce postoperative complications, but sustainability of its health benefits and impact on costs needs further evaluation. Our aim was to assess the midterm clinical impact and costs from a hospital perspective of an endurance-exercise-training-based prehabilitation programme in high-risk patients undergoing major digestive surgery. METHODS: A cost-consequence analysis was performed using secondary data from a randomised, blinded clinical trial. The main outcomes assessed were (i) 30-day hospital readmissions, (ii) endurance time (ET) during an exercise testing, and (iii) physical activity by the Yale Physical Activity Survey (YPAS). Healthcare use for the cost analysis included costs of the prehabilitation programme, hospitalisation, and 30-day emergency room visits and hospital readmissions. RESULTS: We included 125 patients in an intention-to-treat analysis. Prehabilitation showed a protective effect for 30-day hospital readmissions (relative risk: 6.4; 95% confidence interval [CI]: 1.4-30.0). Prehabilitation-induced enhancement of ET and YPAS remained statistically significant between groups at the end of the 3 and 6 month follow-up periods, respectively (ΔET 205 [151] s; P=0.048) (ΔYPAS 7 [2]; P=0.016). The mean cost of the programme was €389 per patient and did not increment the total costs of the surgical process (€812; CI: 95% -878 - 2642; P=0.365). CONCLUSIONS: Prehabilitation may result in health value generation. Moreover, it appears to be a protective intervention for 30-day hospital readmissions, and its effects on aerobic capacity and physical activity may show sustainability at midterm. CLINICAL TRIAL REGISTRATION: NCT02024776.

[Review of the economic evidence on the use of deep brain stimulation in late stage Parkinson's disease]. / Revisión de la evidencia económica sobre el uso de la estimulación cerebral profunda en la enfermedad de Parkinson avanzada.

INTRODUCTION: The purpose of this article is to present the results of a systematic review on the costs and the efficiency of Deep Brain Stimulation (DBS) on patients suffering advanced Parkinson's disease. MATERIAL AND METHOD: A systematic review is performed using databases such as Medline, NHS EED and HTA del Centre for Reviews and Dissemination and Google Scholar from January 2001-2008. RESULTS: Ten articles meet the criteria; one cost description, four cost analyses and five economic evaluations. The scientific evidence shows a reduction in the pharmaceutical costs of those patients treated with DBS. Regarding the direct medical costs, the same statement cannot be made. While some studies estimate the equivalent annual cost of DBS is 54,7% higher than that of traditional therapy, other studies, which include indirect costs such as productivity losses or informal care, claim DBS costs 34,7% less. The incremental cost-effectiveness ratio per QALY is slightly above euro30.000 in 1998 in both the cost-utility analyses where the time horizon was 5 years or more. In the third cost-utility analysis, DBS is the dominant option when the equivalent annual cost was computed. CONCLUSIONS: The available evidence is not strong enough to conclude whether DBS' direct medical costs are higher or lower than the costs of traditional therapy. Key words: Parkinson's disease. Deep brain stimulation. Subthalamic stimulation. Cost analysis. Economic evaluation.

La evaluación económica de medicamentos en reumatología: objetividad, transparencia y utilidad / Economic evaluation of drugs in rheumatology: objectivity, transparency and utility

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Home hospitalisation of exacerbated chronic obstructive pulmonary disease patients.

It was postulated that home hospitalisation (HH) of selected chronic obstructive pulmonary disease (COPD) exacerbations admitted at the emergency room (ER) could facilitate a better outcome than conventional hospitalisation. To this end, 222 COPD patients (3.2% female; 71+/-10 yrs (mean+/-SD)) were randomly assigned to HH (n=121) or conventional care (n=101). During HH, integrated care was delivered by a specialised nurse with the patient's free-phone access to the nurse ensured for an 8-week follow-up period. Mortality (HH: 4.1%; controls: 6.9%) and hospital readmissions (HH: 0.24+/-0.57 controls: 0.38+/-0.70) were similar in both groups. However, at the end of the follow-up period, HH patients showed: 1) a lower rate of ER visits (0.13+/-0.43 versus 0.31+/-0.62); and 2) a noticeable improvement of quality of life (delta St George's Respiratory Questionnaire (SGRQ), -6.9 versus -2.4). Furthermore, a higher percentage of patients had a better knowledge of the disease (58% versus 27%), a better self-management of their condition (81% versus 48%), and the patient's satisfaction was greater. The average overall direct cost per HH patient was 62% of the costs of conventional care, essentially due to fewer days of inpatient hospitalisation (1.7+/-2.3 versus 4.2+/-4.1 days). A comprehensive home care intervention in selected chronic obstructive pulmonary disease exacerbations appears as cost effective. The home hospitalisation intervention generates better outcomes at lower costs than conventional care.

[Vertical integration and contracting-out in generic hospital services in Spain]. / Integración vertical y contratación externa en los servicios generales de los hospitales españoles.

OBJECTIVES: This study examines the factors that influence make or buy decisions corresponding to four generic services (housekeeping, laundry, food services, and maintenance and security) in Spanish hospitals (3,160 transactions in 790 hospitals). METHODS: The empirical estimation of a logistic model based on hospital utility maximization is presented. Factors included in the model are not only those related to transaction costs, but also those related to public intervention and the political dimension. RESULTS: A total of 55.7% of hospitals contracted-out at least one of the generic services. The services most frequently contracted-out were housekeeping and maintenance and security(45.1 and 32.5%, respectively). In contrast, the services (94.3% and 80.1%, respectively). Hospital size (economies of scale), measured by the number of beds, was one of the most important factors influencing make or buy decisions. CONCLUSIONS: We find evidence that economies of scale are related to a higher level of vertical integration, while specialization and for-profit objectives favor the decision to contract-out. The choice of organizational model for laundry services presents a different pattern from that of the other three services. Empirical results show that some asset specificity could be present in laundry services.

Integración vertical y contratación externa en los servicios generales de los hospitales españoles / Vertical integration and contracting-out in generic hospital services in Spain

Objetivos: Este estudio analiza los factores que influyen en las decisiones de integración vertical/contratación externa de cuatro servicios generales (limpieza, lavandería, alimentación y seguridad y mantenimiento) en los hospitales españoles (3.160 transacciones que corresponden a 790 hospitales). Métodos: Se presenta la estimación empírica de un modelo logístico de maximización de la utilidad de los hospitales, en el que intervienen no sólo factores relacionados con los costes de transacción, sino también otros relacionados con la intervención pública y la dimensión política. Resultados: El 55,7% de los hospitales contrata al menos uno de los servicios generales analizados. El servicio de limpieza es el que presenta un mayor grado de contratación externa (45,1%), seguido del servicio de seguridad y mantenimiento (32,5%). En cambio, el servicio de lavandería es el que presenta un mayor grado de integración vertical (94,3%) junto con el de alimentación (..) (AU)

Objectives: This study examines the factors that influence make or buy decisions corresponding to four generic services (housekeeping, laundry, food services, and maintenance and security) in Spanish hospitals (3,160 transactions in 790 hospitals). Methods: The empirical estimation of a logistic model based on hospital utility maximization is presented. Factors included in the model are not only those related to transaction costs, but also those related to public intervention and the political dimension. Results: A total of 55.7% of hospitals contracted-out at least one of the generic services. The services most frequently contracted-out were housekeeping and maintenance and security(45.1 and 32.5%, respectively). In contrast, the services (94.3% and 80.1%, respectively). Hospital size (economies of scale), measured by the number of beds, was one of the most important factors (..) (AU)

Análisis coste-utilidad / Cost-utility analysis

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El establecimiento de prioridades / Establishing priorities

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El análisis coste-beneficio en sanidad / Cost-benefit analysis in health

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El análisis coste-efectividad en sanidad / Cost-effectiveness analysis in health

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Los costes en la evaluación económica de tecnologías sanitarias / Cost of economics evaluation of health technologies

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